📄 Category

developmental biology

188 papers

Developmental biology explores the incredible journey of how a single cell transforms into a complex, living organism. This field investigates the molecular switches and cellular conversations that guide growth, tissue formation, and the emergence of unique body structures, helping us understand both the origins of life and the roots of developmental disorders.

At Gist.Science, we ensure you never miss a breakthrough by processing every new preprint in this category from bioRxiv. Our team provides both plain-language explanations and detailed technical summaries for each paper, making cutting-edge research accessible to everyone regardless of their scientific background.

Below are the latest studies in developmental biology, offering fresh insights into how life takes shape.

📄 developmental biology

Description of the embryonic development in the convict cichlid (Amatitlania nigrofasciata)

This paper presents a detailed description and a practical staging table of the embryonic development of the convict cichlid (*Amatitlania nigrofasciata*) from fertilization to hatching at 26°C, highlighting key temporal milestones such as rapid early cleavage, asymmetric epiboly, and the overlap of somitogenesis with late gastrulation to facilitate future comparative and experimental research.

Matsuo, S., Kusakabe, R., Satoh, S., Kambe, K., Fukuda, K.2026-03-10
📄 developmental biology

Luminal epithelium remodeling underlies endometrial regeneration during menstruation and pregnancy

This study challenges the prevailing gland-centric model by demonstrating that the uterine luminal epithelium maintains its own distinct progenitor population and undergoes extensive expansion and morphogenesis to independently regenerate the endometrium during menstruation and pregnancy, rather than relying on glandular cells for repair.

Ang, C. J., Gable, J. J. R., Lyons, K. C., Miguel Whelan, E., Cevrim, C., Skokan, T. D., Bennetts, S. G., Manetta, B. D. (…)2026-03-10
📄 developmental biology

Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs

This study demonstrates that Hippo signaling differentially regulates distinct SOX9+ progenitor subpopulations and their transitional states to control lung size through bifurcation and specify cell fates for conducting airways and alveolar epithelium, providing a comprehensive developmental map of mammalian lung construction.

Zhang, K., Basak, M., Zaher, Y., Yao, E., Wang, S.-A., Aung, T., Chuang, P.-T.2026-03-08
📄 developmental biology

Distribution-Aware Federated Learning for Diabetes Prediction Using Tabular Clinical Data Under Non-IID and Class-Imbalanced Settings

This paper proposes Distribution-Aware Federated Learning (DA-FL), a novel framework that combines client-specific minority-class amplification factors with class-weighted loss to effectively mitigate non-IID and class-imbalanced challenges in diabetes prediction, significantly outperforming conventional methods like FedAvg in accuracy and stability on the CDC BRFSS 2021 dataset.

Amin, R., Rana, M. M. H., Aktar, S.2026-03-08
📄 developmental biology

Structure and genomic organization of the human DUX4 homologue bovine DUXC

This study characterizes the genomic organization and expression of the bovine DUXC gene in early embryos, providing the first full-length mRNA sequence and demonstrating that DUXC is expressed at pre-embryonic genome activation (EGA) stages with a subsequent decline dependent on minor EGA, suggesting its potential role as a bovine EGA inducer.

Yasar, B., Org, T., Ivask, M., Yazgeldi Gunaydin, G., Boskovic, N., Jaakma, U., Kere, J., Kurg, A., Katayama, S.2026-03-07
📄 developmental biology

Cardiac-immune microniches programme macrophage states in the regenerating heart

This study utilizes high-resolution spatial transcriptomics to reveal that zebrafish heart regeneration relies on the organization of macrophages into discrete cardio-immune microniches, where a specific fibroblast-macrophage axis (il34-csf1ra-egr1) orchestrates pro-regenerative states, while its disruption shifts macrophages toward pro-fibrotic inflammation and impairs tissue repair.

Razaghi, E., Tuzuner, S., Gungoosingh, T., Cil, K., Wong, W. S., Alonaizan, R., Richardson, R., Simoes, F. C.2026-03-07
📄 developmental biology

Skin capillary endothelial cells form a network of spatiotemporally conserved Ca2+ activity

Using intravital multiphoton imaging, this study reveals that skin capillary endothelial cells maintain a spatiotemporally conserved network of Ca2+ activity regulated by Connexin 43-mediated communication, where the loss of Cx43 causes sustained signaling and vascular dysfunction that can be non-cell-autonomously rescued by inhibiting L-type Ca2+ channels.

Swaminathan, A., Gonzalez, D. G., Matte-Martone, C., Xu, F., Simpson, D., Moore, J. L., Lin, Z., Rana, U., Monedero-Alon (…)2026-03-06